!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! Atılım Akademik Arşiv yeni bir platforma taşınmıştır. Erişim linki: https://ada.atilim.edu.tr/home Bilgi için: aysel.senoglu@atilim.edu.tr Atılım Academic Archive has been moved to a new platform. Access link: https://ada.atilim.edu.tr/home For more info: aysel.senoglu@atilim.edu.tr

Browsing by Author "Demir, Mehmet Emin"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Article
    The Evaluation of Serum Endocan, Interleukin-6, and CRP Levels Following Sleeve Gastrectomy
    (International Journal of General Medicine, 2023-10-13) Türkmen-Sarıyıldız, Gülçin; Çiçek-Demir, Canan; Demir, Mehmet Emin; Arslan, Aykut İlker; Banlı, Oktay; Dursun, Ali Doğan
    Background: The excessive accumulation of fat tissue in obesity is the source of chronic low-level inflammation and causes future dysmetabolic and cardiovascular disorders. Removal of this excessive fat tissue with the aid of bariatric surgery (BS) techniques, such as sleeve gastrectomy, may reverse adverse inflammatory outcomes. The aim of this study is to investigate the impact of sleeve gastrectomy on inflammatory markers, specifically endocan, IL-6, and CRP, in individuals with obesity. Methods: Thirty-two patients with class 3 obesity and class 2 obesity + comorbidities were enrolled in the study. Clinical characteristics including age, comorbidity, body mass index (BMI), waist, and hip circumferences of the participants were noted before and 3 months after sleeve gastrectomy. Blood samples were collected during those periods to assess biochemical features such as serum endocan, interleukin-6 (IL-6), C-reactive peptide, fasting insulin, glycosylated hemoglobin A1c levels, and lipid panel. A statistical package program was used for the analysis of those parameters, and p<0.05 was accepted as significant at a 95.0% confidence interval. Results: BMI reduced from 43.55±6.78 to 36.16±6.14 kg/m2 within 3 months following BS (p<0.001). Preoperative serum endocan, IL-6, and CRP levels were correlated with BMI, and in line with BMI reduction, their serum levels decreased after BS (p<0.05). HOMA-IR also reduced after BS, and both in the pre and post-BS periods correlated with BMI, IL-6, endocan, and CRP levels (p<0.05). The mean total body weight loss was 20.4% within 3 months post-BS. Conclusion: BS techniques are effective in weight loss and reversing the inflammatory processes caused by obesity. Serum endocan, IL-6, and CRP levels are promising markers for describing obesity-related inflammation and objectively checking the alleviation of inflammation following BS.