!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! Atılım Akademik Arşiv yeni bir platforma taşınmıştır. Erişim linki: https://ada.atilim.edu.tr/home Bilgi için: aysel.senoglu@atilim.edu.tr Atılım Academic Archive has been moved to a new platform. Access link: https://ada.atilim.edu.tr/home For more info: aysel.senoglu@atilim.edu.tr
 

article.page.titleprefix
Irisin pathways in hearts of Type 1 diabetic adult male rats following 6 weeks of moderate and high-volume aerobic exercise on a treadmill

Simple item page
dc.contributor.authorÇelik, Hümeyra
dc.contributor.authorDursun, Ali Doğan
dc.contributor.authorTatar, Yakup
dc.contributor.authorÖmercioğlu, Göktuğ
dc.contributor.authorBaştuğ, Metin
dc.date.accessioned2023-12-26T09:10:39Z
dc.date.available2023-12-26T09:10:39Z
dc.date.issued2023-06
dc.descriptionPublished by Sport Sciences for Health, https://doi.org/10.1007/s11332-022-00924-1, Humeyra Celik, School of Medicine Physiology Department, Bolu Abant Izzet Baysal University Karaköy, 15 Temmuz Demokrasi Bulvarı, 14030, Merkez/Bolu, Turkey, Ali Doğan Dursun, School of Medicine Physiology Department, Atılım University, Ankara, Turkey, Yakup Tatar, School of Medicine Physiology Department, TOBB University, Ankara, Turkey, Goktug Omercioglu & Metin Bastug, School of Medicine Physiology Department, Ankara University, Ankara, Turkey.
dc.description.abstractPurpose Exercise-mediated protection from cardiomyopathy in diabetes through myokines raises the question of what volume of exercise should be performed. Irisin pathway molecules (consisting of peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), irisin, peroxisome proliferator-activated receptors-α (PPAR-α) and uncoupling protein 1 (UCP1)), which have been shown to be mostly expressed in the heart, are thought to have beneficial effects on diabetic heart. The aim of the study is to evaluate the effects of different exercise protocols on irisin pathway in Type 1 diabetic heart. Methods Diabetic (60 mg/kg streptozotocin i.p.) and healthy Wistar Albino rats (n = 60) were trained under moderate and high-volume exercise protocols on rat treadmill for 6 weeks. After killing, mRNA transcript and protein abundance of PGC-1α, irisin, PPAR-α, and UCP1 were determined in the left ventricles of healthy and diabetic rats. Results PPAR-α, FNDC5, and UCP1 mRNA levels increased significantly in healthy moderate-volume exercise group (HMVE) compared to healthy high-volume exercise (HHVE) and diabetic moderate-volume exercise groups (DMVE). Moreover, protein levels of irisin and UCP1 also elevated significantly in the diabetic high-volume exercise group (DHVE) compared to the healthy control group (HC), although there was no significant difference between the groups in PPAR-α. Conclusion Irisin and UCP1 protein values increased due to HHEV in the heart of Type 1 diabetic rats, but PPAR-α values did not change; it shows that HHEV is suitable for the heart of Type 1 diabetic rats in terms of the benefits of the pathway of irisin.
dc.identifier.citationhttp://hdl.handle.net/20.500.14411/1934
dc.identifier.issn1825-1234
dc.identifier.urihttps://doi.org/10.1007/s11332-022-00924-1
dc.language.isoen
dc.publisherSport Sciences for Health
dc.relation.ispartofseries19
dc.subjectType 1 diabetes mellitus , Exercise intensity, Irisin Diabetic cardiomyopathy, FNDC5, Heart
dc.titleIrisin pathways in hearts of Type 1 diabetic adult male rats following 6 weeks of moderate and high-volume aerobic exercise on a treadmill
dc.typeArticle
dspace.entity.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Ali Doğan Dursun-Irisin Pathways İn Hearts.docx
Size:
47.34 KB
Format:
Microsoft Word XML
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Medical